It sounds counterintuitive, but the breathing reflex actually has nothing to do with how much oxygen you have left in your lungs. Instead your body gauges the level of its end product: carbon dioxide, or CO2. You breathe in oxygen, and you exhale CO2. When you hold your breath, the carbon has nowhere to go, and slowly builds up in your blood. When this reaches a certain threshold (which varies from person to person), socalled chemoreceptors send signals to the respiratory muscles, compelling them to contract and forcing you to breathe. The breathing reflex is therefore also called the hypercapnic drive or CO2 drive.